Identify doublets in single-cell RNA sequencing data
DoubletFinder identifies doublets by generating artificial doublets from existing scRNA-seq data and defining which real cells preferentially co-localize with artificial doublets in gene expression space. Other DoubletFinder package functions are used for fitting DoubletFinder to different scRNA-seq datasets. For example, ideal DoubletFinder performance in real-world contexts requires optimal pK selection and homotypic doublet proportion estimation. pK selection is achieved using pN-pK parameter sweeps and maxima identification in mean-variance-normalized bimodality coefficient distributions. Homotypic doublet proportion estimation is achieved by finding the sum of squared cell annotation frequencies.
System | Target | Derivation | Build status |
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x86_64-linux | /gnu/store/bfif5ai8ni662ayz9b803xxha53fgx7v-r-doubletfinder-2.0.3-1.554097b.drv | ||
i686-linux | /gnu/store/315a56h4bg1vkihzi5ixc1x98wgs5i0p-r-doubletfinder-2.0.3-1.554097b.drv |
Linter | Message | Location |
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No lint warnings ✓ |